Thalidomide-azetidine-C-OH free base

Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

For research use only. Not for human or veterinary use.

Target E3 Ligase Ligand-Linker Conjugates

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Thalidomide-azetidine-C-OH structure

CAS No.: 2241314-93-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 140.00	BP-02197-250mg	In stock	Get quote
500 mg	USD 250.00	BP-02197-500mg	In stock	Get quote
1 g	USD 400.00	BP-02197-1g	In stock	Get quote
2 g	USD 640.00	BP-02197-2g	In stock	Get quote
3 g	USD 760.00	BP-02197-3g	In stock	Get quote
5 g	USD 1,020.00	BP-02197-5g	In stock	Get quote
10 g	USD 1,620.00	BP-02197-10g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

Biological activity

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Identifiers

SMILES: O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CC(CO)C4
InChIKey: FNPPHCWRHBXQJB-UHFFFAOYSA-N

Specifications

MW (average): 343.3340
Formula: C₁₇H₁₇N₃O₅
CAS No.: 2241314-93-0
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

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