BI 99179 free base · Synonyms: BI-99179 · BI99179

BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase inhibitor.

For research use only. Not for human or veterinary use.

Target Fatty Acid Synthase (FASN)

Research area Metabolic Disease Cancer

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Data Sheet SDS COA

BI 99179 structure

CAS No.: 1291779-76-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 580.00	BP-02185-250mg	In stock	Get quote
500 mg	USD 920.00	BP-02185-500mg	In stock	Get quote
1 g	USD 1,460.00	BP-02185-1g	In stock	Get quote
2 g	USD 2,350.00	BP-02185-2g	In stock	Get quote
3 g	USD 2,850.00	BP-02185-3g	In stock	Get quote
5 g	USD 3,800.00	BP-02185-5g	In stock	Get quote

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Description

BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .

Biological activity

In Vitro BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM. BI 99179 (BI-99179; 1, 2, and 4 μM) shows antiproliferative efficacy in human glioma GAMG cells. In Vivo BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t1/2) of 3.0 h.

Identifiers

SMILES: O=C([C@H]1C[C@@H](NC(CC)=O)CC1)N(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C
InChIKey: YNFDIGJKJPNFFD-SJORKVTESA-N

Specifications

MW (average): 391.4629
Formula: C₂₃H₂₅N₃O₃
CAS No.: 1291779-76-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

[2]. Prosanta K Singha, et al. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells. Eur J Pharm Sci. 2020 Apr 7;149:105321.

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