ARC 239 free base · Synonyms: ARC-239 · ARC239

ARC 239 is an α2B/C-adrenergic receptor antagonist.

For research use only. Not for human or veterinary use.

Target Adrenergic Receptor5-HT Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

ARC 239 structure

CAS No.: 67339-62-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 830.00	BP-02209-100mg	In stock	Get quote
250 mg	USD 1,650.00	BP-02209-250mg	In stock	Get quote
500 mg	USD 2,650.00	BP-02209-500mg	In stock	Get quote
1 g	USD 4,250.00	BP-02209-1g	In stock	Get quote

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Description

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

Identifiers

SMILES: O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
InChIKey: JFNKXGOEOQCXDM-UHFFFAOYSA-N

Specifications

MW (average): 407.5054
Formula: C₂₄H₂₉N₃O₃
CAS No.: 67339-62-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. K T Gavin, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):406-11.

[2]. J J Meana, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312(3):385-8.

Same research area

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