EML4-ALK kinase inhibitor 1 free base

EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase.

For research use only. Not for human or veterinary use.

Target Anaplastic lymphoma kinase (ALK)

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

EML4-ALK kinase inhibitor 1 structure

CAS No.: 1373409-08-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 480.00	BP-00030-25mg	In stock	Get quote
50 mg	USD 720.00	BP-00030-50mg	In stock	Get quote
100 mg	USD 1,050.00	BP-00030-100mg	In stock	Get quote
250 mg	USD 1,700.00	BP-00030-250mg	In stock	Get quote
500 mg	USD 2,500.00	BP-00030-500mg	In stock	Get quote
1 g	USD 3,600.00	BP-00030-1g	In stock	Get quote

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Description

EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM.

Identifiers

SMILES: N(C=1C(C(N)=O)=NC(CC)=C(N[C@@H]2CC[C@@H](OC)CC2)N1)C3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(C)CC5
InChIKey: KBHZCRDGGWIHQF-SAIGFBBZSA-N

Specifications

MW (average): 580.7646
Formula: C₃₁H₄₈N₈O₃
CAS No.: 1373409-08-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 110 mg/mL

Documents

References

[1]. Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-169

Same target

Search Anaplastic lymphoma kinase (ALK)

Same research area

Search Cancer