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Lenalidomide-C5-NH2 free base · Synonyms: E3 Ligand-Linker Conjugate 4

Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate.

For research use only. Not for human or veterinary use.

Target E3 Ligase Ligand-Linker Conjugates
Research area Others Cancer
Purity >98% Stock Inquire
Data Sheet SDS COA

Lenalidomide-C5-NH2 structure

CAS No.: 2093388-45-3

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
250 mg USD 560.00 BP-01477-250mg In stock Get quote
500 mg USD 880.00 BP-01477-500mg In stock Get quote
1 g USD 1,420.00 BP-01477-1g In stock Get quote
2 g USD 2,250.00 BP-01477-2g In stock Get quote
3 g USD 2,700.00 BP-01477-3g In stock Get quote
5 g USD 3,650.00 BP-01477-5g In stock Get quote

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Description

Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .

Biological activity

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Identifiers

SMILES
O=C1NC(=O)C(N2C(=O)C3=CC=CC(=C3C2)CCCCCN)CC1
InChIKey
ZZXXBKHLDNFHCQ-UHFFFAOYSA-N

Specifications

MW (average)
329.3935
Formula
C18H23N3O3
CAS No.
2093388-45-3
Physical state
Solid
Color
Light yellow to yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder -20°C, stored under nitrogen; In solvent -20℃, 1 month;

Solubility

soluble in DMSO/H2O

Documents

References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
[2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.

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