SLF Exclusive free base

SLF is a synthetic ligand.

For research use only. Not for human or veterinary use.

Target Ligands for Target Protein for PROTAC FKBP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

SLF Exclusive structure

CAS No.: 195513-96-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 450.00	BP-00006-50mg	In stock	Get quote
100 mg	USD 780.00	BP-00006-100mg	In stock	Get quote
250 mg	USD 1,380.00	BP-00006-250mg	In stock	Get quote
500 mg	USD 1,980.00	BP-00006-500mg	In stock	Get quote
1 g	Inquire	BP-00006-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.

Biological activity

In Vitro Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation

Identifiers

SMILES: C(C(C(CC)(C)C)=O)(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(N)=CC=C3)=O)CCCC1
InChIKey: IIDSDBBDZNDWCN-BJKOFHAPSA-N

Specifications

MW (average): 524.6484
Formula: C₃₀H₄₀N₂O₆
CAS No.: 195513-96-3
Physical state: Oil
Color: Colorless to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Pure form -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.

[2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95.

[3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Same target

Search Ligands for Target Protein for PROTAC

Same research area

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