SB 328437 free base · Synonyms: SB-328437 · SB328437

SB-328437 is a potent, selective non-peptide CCR3 antagonist.

For research use only. Not for human or veterinary use.

Target CCR Thymidylate Synthase

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

SB 328437 structure

CAS No.: 247580-43-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 420.00	BP-00037-50mg	In stock	Get quote
100 mg	USD 670.00	BP-00037-100mg	In stock	Get quote
250 mg	USD 1,280.00	BP-00037-250mg	In stock	Get quote
500 mg	USD 1,900.00	BP-00037-500mg	In stock	Get quote
1 g	USD 2,800.00	BP-00037-1g	In stock	Get quote
2 g	USD 4,500.00	BP-00037-2g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases.

Biological activity

In Vitro SB-328437 (50 μM; 72 h) can reduce the viability of 5-FU-resistant AGS cells and inhibit the mRNA levels of CCR3 and thymidylate synthase, when used in combination with 5-FU (HY-90006). In Vivo SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection.

Identifiers

SMILES: C(N[C@@H](CC1=CC=C(N(=O)=O)C=C1)C(OC)=O)(=O)C=2C3=C(C=CC2)C=CC=C3
InChIKey: VMFGCGRAIBLAFY-IBGZPJMESA-N

Specifications

MW (average): 378.3780
Formula: C₂₁H₁₈N₂O₅
CAS No.: 247580-43-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 87.5 mg/mL

Documents

References

[1]. Gutiérrez ?, et al. Targeting CCR3 with antagonist SB 328437 sensitizes 5?fluorouracil?resistant gastric cancer cells: Experimental evidence and computational insights. Oncol Lett. 2024 May 1;28(1):296.

[2]. Lopez-Leal F, et al. Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation. J Leukoc Biol. 2024 Nov 4;116(5):1198-1207.

[3]. White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275(47):36626-31.

Same target

Search CCR

Same research area

Search Inflammation/Immunology