BMS 605541 free base · Synonyms: BMS-605541 · BMS605541

BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase.

For research use only. Not for human or veterinary use.

Target VEGFR PDGFR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BMS 605541 structure

CAS No.: 639858-32-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 320.00	BP-02208-250mg	In stock	Get quote
500 mg	USD 510.00	BP-02208-100mg	In stock	Get quote
1 g	USD 815.00	BP-02208-1g	In stock	Get quote
2 g	USD 1,310.00	BP-02208-2g	In stock	Get quote
3 g	USD 1,560.00	BP-02208-3g	In stock	Get quote
5 g	USD 2,090.00	BP-02208-5g	In stock	Get quote
10 g	USD 3,350.00	BP-02208-10g	In stock	Get quote

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Description

BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].

Biological activity

In Vitro BMS-605541 (Compound 14) inhibits the growth of HUVECs through VEGF with an IC50 value of 25 nM. In Vivo BMS-605541 (12.5-180 mg/kg; once a day or twice a day for 14 days) has anti-tumor activity in thymic mice subcutaneously implanted with L2987 and HCT-116 xenografts.

Identifiers

SMILES: FC1=C(C=C(C(F)=C1)C(NC2CC2)=O)NCC3=CN=C(S3)NC4=NC=CC=C4
InChIKey: CUPLTRAPYIXFAX-UHFFFAOYSA-N

Specifications

MW (average): 401.4330
Formula: C₁₉H₁₇F₂N₅OS
CAS No.: 639858-32-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9.

Same target

Search VEGFR

Same research area

Search Cancer