MDK7526 HCl salt form · salt · Parent VH032-NH2 · Synonyms: VHL ligand 1 hydrochloride | (S,R,S)-AHPC hydrochloride

MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.

For research use only. Not for human or veterinary use.

Target Ligands for E3 Ligase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MDK7526 HCl structure

CAS No.: 1448189-80-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 g	USD 850.00	BP-01893A-25g	In stock	Get quote
50 g	USD 1,500.00	BP-01893A-50g	In stock	Get quote
100 g	USD 2,400.00	BP-01893A-100g	Inquire	Get quote
250 g	USD 4,850.00	BP-01893A-250g	Inquire	Get quote

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Related forms

BP-01893 — VH032-NH2

Description

MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.

Biological activity

In Vitro The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

Identifiers

SMILES: Cl.CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)C=C1
InChIKey: JYRTWGCWUBURGU-MSSRUXLCSA-N

Specifications

MW (average): 467.0250
Formula: C₂₂H₃₁ClN₄O₃S
CAS No.: 1448189-80-7
Physical state: Solid
Color: white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO/H2O

Documents

References

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

[2]. Krieger J, et al. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. ChemMedChem. 2023 Apr 17;18(8):e202200615.

[3]. Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers[J]. J Med Chem. 2023 Sep 28;66(18):12776-12811.

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