NSC-339004 free base · Synonyms: NSC 339004 · NSC339004

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison.

For research use only. Not for human or veterinary use.

Target Molecular Glues Topoisomerase Parasite

Research area Infection Cancer

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Data Sheet SDS COA

NSC-339004 structure

CAS No.: 97919-22-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 445.00	BP-00008-50mg	In stock	Get quote
100 mg	USD 700.00	BP-00008-100mg	In stock	Get quote
250 mg	USD 1,420.00	BP-00008-250mg	In stock	Get quote
500 mg	USD 2,280.00	BP-00008-500mg	In stock	Get quote
1 g	USD 3,650.00	BP-00008-1g	In stock	Get quote
2 g	Inquire	BP-00008-2g	In stock	Inquire

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Description

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.

Biological activity

In Vitro The Chloroquinoxaline sulfonamide IC50 for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links. Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used.

Identifiers

SMILES: O=S(=O)(NC1=NC2=CC=CC(Cl)=C2N=C1)C3=CC=C(N)C=C3
InChIKey: CTSNHMQGVWXIEG-UHFFFAOYSA-N

Specifications

MW (average): 334.7810
Formula: C₁₄H₁₁ClN₄O₂S
CAS No.: 97919-22-7
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 125 mg/mL

Documents

References

[1]. Gao H, et al. Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer?Res. 2000 Nov 1;60(21):5937-40.

[2]. Branda RF, et al. Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells. Biochem Pharmacol. 1988 Dec 1;37(23):4557-64.

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