(S,R,S)-AHPC-Me-C6-NH2 free base

(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 .

For research use only. Not for human or veterinary use.

Target E3 Ligase Ligand-Linker Conjugates

Research area Others

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Data Sheet SDS COA

(S,R,S)-AHPC-Me-C6-NH2 structure

CAS No.: 2411422-49-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 480.00	BP-02150-25mg	In stock	Get quote
50 mg	USD 750.00	BP-02150-50mg	In stock	Get quote
100 mg	USD 1,200.00	BP-02150-100mg	In stock	Get quote
250 mg	USD 2,350.00	BP-02150-250mg	In stock	Get quote
500 mg	USD 3,600.00	BP-02150-500mg	In stock	Get quote
1 g	Inquire	BP-02150-1g	In stock	Inquire

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Description

(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 . (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .

Biological activity

In Vitro (S,R,S)-AHPC-Me-C6-NH2 is used to couple with oseltamivir moieties via amide condensation to construct Oseltamivir (HY-13317)-PROTACs, which induce the degradation of viral neuraminidase (NA), inhibit influenza virus replication in MDCK cells, and show potent inhibitory activity against both wild-type and Oseltamivir-resistant influenza strains in vitro.

Identifiers

SMILES: NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
InChIKey: UGZLQBJANUBKTH-BOALBMDWSA-N

Specifications

MW (average): 571.7740
Formula: C₃₀H₄₅N₅O₄S
CAS No.: 2411422-49-4
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Poeder -20°C, sealed storage, away from moisture; In solvent -20°C, 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Haibing Zhou, et al. Oseltamivir PROTAC compound, preparation method thereof and application thereof in anti-influenza virus drugs. Patent CN112592331A.

[2].Bondeson DP, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022;13(1):5495. Published 2022 Sep 20.

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