(S,R,S)-AHPC-Me-C6-NH2 free base
(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 .
For research use only. Not for human or veterinary use.
(S,R,S)-AHPC-Me-C6-NH2 structure
CAS No.: 2411422-49-4
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 480.00 | BP-02150-25mg | In stock | Get quote |
| 50 mg | USD 750.00 | BP-02150-50mg | In stock | Get quote |
| 100 mg | USD 1,200.00 | BP-02150-100mg | In stock | Get quote |
| 250 mg | USD 2,350.00 | BP-02150-250mg | In stock | Get quote |
| 500 mg | USD 3,600.00 | BP-02150-500mg | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 . (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .
Biological activity
In Vitro (S,R,S)-AHPC-Me-C6-NH2 is used to couple with oseltamivir moieties via amide condensation to construct Oseltamivir (HY-13317)-PROTACs, which induce the degradation of viral neuraminidase (NA), inhibit influenza virus replication in MDCK cells, and show potent inhibitory activity against both wild-type and Oseltamivir-resistant influenza strains in vitro.
Identifiers
- SMILES
-
NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O - InChIKey
-
UGZLQBJANUBKTH-BOALBMDWSA-N
Specifications
- MW (average)
- 571.7740
- Formula
- C30H45N5O4S
- CAS No.
- 2411422-49-4
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Poeder -20°C, sealed storage, away from moisture; In solvent -20°C, 1 month;
Solubility
Soluble in DMSO