(S,R,S)-AHPC-C4-COOH free base

(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL…

For research use only. Not for human or veterinary use.

Target E3 Ligase Ligand-Linker Conjugates

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(S,R,S)-AHPC-C4-COOH structure

CAS No.: 2172819-74-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 570.00	BP-02400-500mg	In stock	Get quote
1 g	USD 918.00	BP-02400-1g	In stock	Get quote
2 g	USD 1,470.00	BP-02400-2g	In stock	Get quote
3 g	USD 1,764.00	BP-02400-3g	In stock	Get quote
5 g	USD 2,350.00	BP-02400-5g	In stock	Get quote
10 g	USD 3,760.00	BP-02400-10g	In stock	Get quote

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Description

(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC .

Biological activity

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Identifiers

SMILES: OC(CCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
InChIKey: DKSZOQIYZOVHOL-TYBLODHISA-N

Specifications

MW (average): 558.6900
Formula: C₂₈H₃₈N₄O₆S
CAS No.: 2172819-74-6
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 2 month

Documents

References

[1].Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03

Same target

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