SN38-COOH free base

SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs).

For research use only. Not for human or veterinary use.

Target Drug-Linker Conjugates for ADC

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

SN38-COOH structure

CAS No.: 2170118-23-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 445.00	BP-02447-250mg	In stock	Get quote
500 mg	USD 712.00	BP-02447-500mg	In stock	Get quote
1 g	USD 1,140.00	BP-02447-1g	In stock	Get quote
2 g	USD 1,822.00	BP-02447-2g	In stock	Get quote
3 g	USD 2,187.00	BP-02447-3g	In stock	Get quote
5 g	USD 2,920.00	BP-02447-5g	In stock	Get quote
10 g	Inquire	BP-02447-10g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis .

Identifiers

SMILES: OC(CCC(O[C@]1(C2=C(COC1=O)C(N3C(C(C(C3)=C(C4=C5)CC)=NC4=CC=C5O)=C2)=O)CC)=O)=O
InChIKey: AOWPNVSSWGMHGV-SANMLTNESA-N

Specifications

MW (average): 492.4774
Formula: C₂₆H₂₄N₂O₈
CAS No.: 2170118-23-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Wilson Lim, et al. Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. PLoS Negl Trop Dis. 2018 Apr 26;12(4):e0006437.

[2]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8.

Same target

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Same research area

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