NAMPT inhibitor-linker 2 free base

NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.

For research use only. Not for human or veterinary use.

Target NAMPT Drug-Linker Conjugates for ADC

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NAMPT inhibitor-linker 2 structure

CAS No.: 2241014-82-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 460.00	BP-02443-10mg	In stock	Get quote
25 mg	USD 920.00	BP-02443-25mg	In stock	Get quote
50 mg	USD 1,470.00	BP-02443-50mg	In stock	Get quote
100 mg	USD 2,350.00	BP-02443-100mg	In stock	Get quote
250 mg	USD 4,710.00	BP-02443-250mg	In stock	Get quote
500 mg	Inquire	BP-02443-500mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.

Biological activity

In Vitro ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively. ADC-4 (0.01 nM-10 nM, 144 hours) inhibits cell proliferation of GIST-T1 cells, but does not affect the cell cycle. In Vivo ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.

Identifiers

SMILES: FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O
InChIKey: BCYXMGSOTBLGDN-IZLXSDGUSA-N

Specifications

MW (average): 624.6614
Formula: C₃₄H₃₃FN₆O₅
CAS No.: 2241014-82-2
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 50 mg/mL

Documents

References

[1].Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

Same target

Search NAMPT

Same research area

Search Cancer