Opadotin free base · Synonyms: Amberstatin 269 | AS 269

PEG4-aminooxy-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the…

For research use only. Not for human or veterinary use.

Target Microtubule/Tubulin Drug-Linker Conjugates for ADC

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Opadotin structure

CAS No.: 1415246-35-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 1,450.00	BP-00343-50mg	In stock	Get quote
100 mg	USD 2,585.00	BP-00343-100mg	In stock	Get quote
250 mg	Inquire	BP-00343-250mg	In stock	Inquire
500 mg	Inquire	BP-00343-500mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

PEG4-aminooxy-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4 .

Biological activity

In Vitro Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin.

Identifiers

SMILES: [C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(CCOCCOCCOCCON)C)[C@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
InChIKey: OJYZGXVPCDZLCK-KVEFUIBJSA-N

Specifications

MW (average): 923.1870
Formula: C₄₇H₈₂N₆O₁₂
CAS No.: 1415246-35-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Mukherjee A, et al. Targeted Therapy in Breast Cancer: Advantages and Advancements of Antibody-Drug Conjugates, a Type of Chemo-Biologic Hybrid Drugs. Cancers (Basel). 2024 Oct 17;16(20):3517.

Same research area

Search Inflammation/Immunology