MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan free base

MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan is a agent-linker conjugate for ADC, contains the ADC linker…

For research use only. Not for human or veterinary use.

Target Drug-Linker Conjugates for ADC Topoisomerase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan structure

CAS No.: 2414393-22-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 650.00	BP-00353-50mg	In stock	Get quote
100 mg	USD 998.00	BP-00353-100mg	In stock	Get quote
250 mg	USD 1,688.00	BP-00353-250mg	In stock	Get quote
500 mg	Inquire	BP-00353-500mg	In stock	Inquire
1 g	Inquire	BP-00353-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan is a agent-linker conjugate for ADC, contains the ADC linker (MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic acid) and a DNA topoisomerase I inhibitor Exatecan. MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan synthesized ADC can be used in study of cancer.

Biological activity

In Vitro Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin

Identifiers

SMILES: O=C(C1(CCC1)OCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95
InChIKey: DBCVGCVTFAJVMD-HKMBIKTJSA-N

Specifications

MW (average): 1074.1158
Formula: C₅₅H₆₀FN₉O₁₃
CAS No.: 2414393-22-7
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture and light; In solvent -20℃, 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. HUA Haiqing, et al. Antibody-drug conjugate and medical use thereof. Patent WO2021190564A1.

Same target

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Same research area

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