Fmoc-GGFG-Dxd free base · Synonyms: Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc

Fmoc-GGFG-Dxd is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group.

For research use only. Not for human or veterinary use.

Target Drug-Linker Conjugates for ADC

Research area Cancer

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Data Sheet SDS COA

Fmoc-GGFG-Dxd structure

CAS No.: 1599440-11-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 385.00	BP-02366-25mg	In stock	Get quote
50 mg	USD 885.00	BP-02366-50mg	In stock	Get quote
100 mg	USD 950.00	BP-02366-100mg	In stock	Get quote
250 mg	USD 1,550.00	BP-02366-250mg	In stock	Get quote
1 g	Inquire	BP-02366-1g	In stock	Inquire

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Description

Fmoc-GGFG-Dxd is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.

Biological activity

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Identifiers

SMILES: O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O
InChIKey: TVZRZUVAYRAILT-XWCAFGSDSA-N

Specifications

MW (average): 1063.0914
Formula: C₅₇H₅₅FN₈O₁₂
CAS No.: 1599440-11-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 175 mg/mL

Documents

References

[1]. Lingpei Kong, et al. Synthetic method for antibody-conjugated drug linker LND1067. CN113336823A.

Same target

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Same research area

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