NAMPT inhibitor-linker 1 free base

NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.

For research use only. Not for human or veterinary use.

Target Drug-Linker Conjugates for ADC

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NAMPT inhibitor-linker 1 structure

CAS No.: 2241019-57-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 550.00	BP-02388-5mg	In stock	Get quote
10 mg	USD 798.00	BP-02388-10mg	In stock	Get quote
25 mg	USD 1,585.00	BP-02388-25mg	In stock	Get quote
50 mg	Inquire	BP-02388-50mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

Biological activity

In Vitro ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively. In Vivo ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells

Identifiers

SMILES: C(NC1=CC(F)=C(CNC(=O)C2=CC=C(C=C2)N3CCN(C(CCOCCN4C(=O)C=CC4=O)=O)CC3)C=C1)(=O)[C@@H]5[C@H](C5)C=6C=CC=NC6
InChIKey: ZIJGVXBDFVHKQP-IHLOFXLRSA-N

Specifications

MW (average): 668.7140
Formula: C₃₆H₃₇FN₆O₆
CAS No.: 2241019-57-6
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, stored under nitrogen; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO

In vitro: DMSO : 12.5 mg/mL

Documents

References

[1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

Same target

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Same research area

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