Nampt-IN-10 free base

Nampt-IN-10 is an efficient inhibitor of nicotinamide phosphoribosyltransferase.

For research use only. Not for human or veterinary use.

Target ADC Payloads NAMPT

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Nampt-IN-10 structure

CAS No.: 2241015-68-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 360.00	BP-02419-10mg	In stock	Get quote
25 mg	USD 720.00	BP-02419-25mg	In stock	Get quote
50 mg	USD 1,150.00	BP-02419-50mg	In stock	Get quote
100 mg	USD 1,840.00	BP-02419-100mg	In stock	Get quote
250 mg	USD 3,680.00	BP-02419-250mg	In stock	Get quote
500 mg	USD 5,900.00	BP-02419-500mg	In stock	Get quote
1 g	USD 9,440.00	BP-02419-1g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity .

Identifiers

SMILES: FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O
InChIKey: ARWBPOZZWODTNY-RPWUZVMVSA-N

Specifications

MW (average): 473.5419
Formula: C₂₇H₂₈FN₅O₂
CAS No.: 2241015-68-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Documents

References

[1].Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

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