Tavapadon free base · Synonyms: PF-6649751 (Rotation -) | CVL-751 (Rotation -)

Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist.

For research use only. Not for human or veterinary use.

Target Dopamine Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Tavapadon structure

CAS No.: 1643489-24-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 580.00	BP-01917-500mg	In stock	Get quote
1 g	USD 920.00	BP-01917-1g	In stock	Get quote
2 g	USD 1,620.00	BP-01917-2g	In stock	Get quote
5 g	Inquire	BP-01917-5g	In stock	Inquire
10 g	Inquire	BP-01917-10g	Inquire	Inquire

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Description

Tavapadon (PF-6649751; CVL-751; Rotation -) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease.

Biological activity

In Vivo Tavapadon (PF-06649751; 0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect. Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration. Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) leads to statistically significant improvement relative to vehicle in locomotor activity. Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques.

Identifiers

SMILES: O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O
InChIKey: AKQXQLUNFKDZBN-UHFFFAOYSA-N

Specifications

MW (average): 391.3438
Formula: C₁₉H₁₆F₃N₃O₃
CAS No.: 1643489-24-0
Physical state: Solid
Color: White to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO, not in water

Documents

References

[1]. Young D, et al. D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited DyskinesiaSide Effects. ACS Chem Neurosci. 2020 Feb 19;11(4):560-566.

Same research area

Search Neurological Disease