CHDI 00484077 free base · Synonyms: CHDI-00484077 · CHDI00484077
CHDI-00484077 is a CNS-penetrant class IIa HDAC inhibitor.
For research use only. Not for human or veterinary use.
Target
HDAC
Research area
Neurological Disease
Purity >98%
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CHDI 00484077 structure
CAS No.: 3025894-92-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 5 mg | USD 350.00 | BP-00025-5mg | In stock | Get quote |
| 10 mg | USD 560.00 | BP-00025-10mg | In stock | Get quote |
| 25 mg | USD 750.00 | BP-00025-25mg | In stock | Get quote |
| 50 mg | USD 1,150.00 | BP-00025-50mg | In stock | Get quote |
| 100 mg | Inquire | BP-00025-100mg | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor, with IC50s of 0.01 μM (HDAC4), 0.02 μM(HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9) respectively. CHDI-00484077 can be used for research of huntington’s disease.
Identifiers
- SMILES
-
C(F)(F)(F)C1=NC(=NO1)C2=CC=C(C(N[C@@H](CN3[C@@H](C)CCC3)C)=O)C=C2 - InChIKey
-
DBWSFWPXCPNWRZ-NEPJUHHUSA-N
Specifications
- MW (average)
- 382.3801
- Formula
- C18H21F3N4O2
- CAS No.
- 3025894-92-9
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO : 10.71 mg/mL
Documents
References
[1]. Stott AJ, et al. Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett. 2021 Feb 11;12(3):380-388.