Mesdopetam hemitartrate free base · Synonyms: Mesdopetam L-tartrate salt | Mesdopetam · 1/2 L-tartrate salt

Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor.

For research use only. Not for human or veterinary use.

Target Dopamine Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Mesdopetam hemitartrate structure

CAS No.: 2562346-14-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 520.00	BP-02030-250mg	In stock	Get quote
500 mg	USD 780.00	BP-02030-500mg	In stock	Get quote
1 g	USD 1,150.00	BP-02030-1g	In stock	Get quote

Custom Size Bulk Inquiry

Description

Mesdopetam hemitartrate (IRL790 hemitartrate) is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.

Biological activity

Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80

Identifiers

SMILES: OC([C@H](O)[C@@H](O)C(O)=O)=O.CCCNCCOC1=CC(S(C)(=O)=O)=CC(F)=C1.CCCNCCOC2=CC(S(C)(=O)=O)=CC(F)=C2
InChIKey: OEGCTXJJFKXVFI-CEAXSRTFSA-N

Specifications

MW (average): 425.4260
Formula: C₁₆H₂₄FNO₉S
CAS No.: 2562346-14-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture

Solubility

Soluble in H2O : 100 mg/mL DMSO : 20.83 mg/mL

Documents

References

[1]. Waters S, Sonesson C, Svensson P, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020;374(1):113-125. doi:10.1124/jpet.119.264226

[2]. Becanovic K, Vittoria de Donno M, Sousa VC, Tedroff J, Svenningsson P. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133. doi:10.1124/jpet.119.264754

Same target

Search Dopamine Receptor

Same research area

Search Neurological Disease