Rotigotine hydrochloride salt form · hydrochloride · Parent Rotigotine hydrochloride · Synonyms: N-0923 Hydrochloride

Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist…

For research use only. Not for human or veterinary use.

Target Dopamine Receptor Adrenergic Receptor 5-HT Receptor

Research area Neurological Disease Endocrinology

Purity >98% Stock Inquire

Rotigotine hydrochloride structure

CAS No.: 125572-93-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 360.00	BP-02313A-500mg	In stock	Get quote
1 g	USD 570.00	BP-02313A-1g	In stock	Get quote
2 g	USD 921.00	BP-02313A-2g	In stock	Get quote
3 g	USD 1,100.00	BP-02313A-3g	In stock	Get quote
5 g	USD 1,475.00	BP-02313A-5g	In stock	Get quote
10 g	USD 2,350.00	BP-02313A-10g	In stock	Get quote

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Description

Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

Biological activity

In Vitro Rotigotine (N-0923) has a 10-fold selectivity for D3 (pKi 9.2) receptors compared with D2, D4 and D5 (pKi 8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi 7.2). In functional studies, Rotigotine (N-0923) behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (N-0923) (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. In Vivo In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats.

Identifiers

SMILES: Cl[H].CCCN(CCC1=CC=CS1)[C@H]1CCC2=C(O)C=CC=C2C1
InChIKey: CEXBONHIOKGWNU-NTISSMGPSA-N

Specifications

MW (average): 351.9340
Formula: C₁₉H₂₆ClNOS
CAS No.: 125572-93-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

CoA On request
Handling Instructions

References

[1]. Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.

[2]. Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.

[3]. Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.

[4]. Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP? and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.

Same target

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Same research area

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