MC3138 free base · Synonyms: MC-3138 · MC 3138

MC3138 is a selective SIRT5 activator.

For research use only. Not for human or veterinary use.

Target Sirtuin

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MC3138 structure

CAS No.: 1844889-12-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 465.00	BP-01936-100mg	In stock	Get quote
250 mg	USD 685.00	BP-01936-250mg	In stock	Get quote
500 mg	USD 985.00	BP-01936-500mg	In stock	Get quote
1 g	Inquire	BP-01936-1g	In stock	Inquire

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Description

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine significantly inhibits tumor growth in mice .

Biological activity

MC3138 (10 μM, 24 h) decreases lysine acetylation of the GOT1 protein and inhibits its enzymatic activity in PDAC cells[1].

Identifiers

SMILES: CCOC(=O)C1=CN(C=C(C1C2=CC(=CC=C2)OC)C(=O)OCC)C(=O)C3=CC=CC=C3
InChIKey: WDDDSHYKJNGLJR-UHFFFAOYSA-N

Specifications

MW (average): 435.4691
Formula: C₂₅H₂₅NO₆
CAS No.: 1844889-12-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃, sealed, 3 years; 4℃, sealed, 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO, >50 mg/mL

Documents

References

[1]. Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600.

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