AS-0141 free base · Synonyms: Monzosertib | SRA141

AS-0141 is a potent Cdc7 kinase inhibitor (IC50=4 nM) extracted from patent WO2019165473A1(compound I- D) with anti-tumor activity.

For research use only. Not for human or veterinary use.

Target CDK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AS-0141 structure

CAS No.: 1402057-88-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 495.00	BP-01882-50mg	In stock	Get quote
100 mg	USD 795.00	BP-01882-100mg	In stock	Get quote
250 mg	USD 1,950.00	BP-01882-250mg	In stock	Get quote
1 g	Inquire	BP-01882-1g	In stock	Inquire

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Description

AS-0141 is a potent Cdc7 kinase inhibitor (IC50=4 nM) extracted from patent WO2019165473A1(compound I- D) with anti-tumor activity.

Biological activity

AS-0141 demonstrates potent inhibitory activity (IC50<3 µΜ) across a variety of solid tumor cell lines, including sarcoma (143B, CADO-ES1, RD-ES, A673), bladder (5673, RT1 12/84), colon and cecum (Colo-205, DLD-1, LS1034, SK-CO-1, SNU-C1), renal (U0.31), melanoma (A2058, A875), head-and-neck (CNE-2Z, RPMI-2650), and gastric (HGC-27) lineages.

Identifiers

SMILES: O=C(C(C/1=O)=C(NN2CCN(CC(F)(F)F)CC2)OC1=C/C3=CNC4=C3C=CC=N4)OCC
InChIKey: DNTVXDZWVOVLOD-GDNBJRDFSA-N

Specifications

MW (average): 465.4257
Formula: C₂₁H₂₂F₃N₅O₄
CAS No.: 1402057-88-8
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Takayuki Irie, et al. Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers. J Med Chem. 2021 Oct 14;64(19):14153-14164.

[2]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.

Same target

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Same research area

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