S-Amisulpride free base · Synonyms: Esamisulpride | 839938 | (S)-Amisulpride

-Amisulpride is a potent dopamine D2/D3 receptor antagonist.

For research use only. Not for human or veterinary use.

Target Dopamine Receptor 5-HT Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

S-Amisulpride structure

CAS No.: 71675-92-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 535.00	BP-02081-250mg	In stock	Get quote
500 mg	USD 735.00	BP-02081-500mg	In stock	Get quote
1 g	USD 1,050.00	BP-02081-1g	In stock	Get quote

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Description

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.

Biological activity

In Vitro Esamisulpride is a 5-HT7 receptor antagonist with a Ki of 900 nM. In Vivo Esamisulpride (10 mg/kg; s.c.) acts as a discriminative stimulus in male C57BL/6 mice, with dose-related, time-dependent (effective between 30 and 120 min) and stereoselective effects.

Identifiers

SMILES: CCN1CCC[C@H]1CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O
InChIKey: NTJOBXMMWNYJFB-LBPRGKRZSA-N

Specifications

MW (average): 369.4790
Formula: C₁₇H₂₇N₃O₄S
CAS No.: 71675-92-8
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22.

[2]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7. ACS Omega. 2019 Aug 15;4(9):14151-14154.

[3]. Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110(3):808-815.

Same target

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Same research area

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