PHGDH-IN-5 free base · Synonyms: CPDP802335

PHGDH-IN-5 is a covalen inhibitor of PHGDH.

For research use only. Not for human or veterinary use.

Target Phosphoglycerate Dehydrogenase (PHGDH)

Research area Cancer

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Data Sheet SDS COA

PHGDH-IN-5 structure

CAS No.: 17402-86-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 425.00	BP-01927-100mg	In stock	Get quote
250 mg	USD 725.00	BP-01927-250mg	In stock	Get quote
500 mg	USD 1,125.00	BP-01927-500mg	In stock	Get quote
1 g	USD 1,985.00	BP-01927-1g	In stock	Get quote
2 g	Inquire	BP-01927-2g	In stock	Inquire

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Description

PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells.

Biological activity

In Vitro PHGDH-IN-5 can inhibit the proliferation of MDA-MB-468, NCI-H1975, HT1080, and PC9 cells, with IC50 values ranging from 9.93 μM to 21.2 μM. PHGDH-IN-5 (10-30 μM) reduces the production of M+3-serine derived from 13C6-glucose in MDA-MB-468 cells[1].

Identifiers

SMILES: O=S1(C2=CC=CC([N+]([O-])=O)=C2C=C1)=O
InChIKey: LWKOZDAODXAJCF-UHFFFAOYSA-N

Specifications

MW (average): 211.1950
Formula: C₈H₅NO₄S
CAS No.: 17402-86-7
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Cao XY, et al. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg Chem. 2024;146:107330.

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