Bromopride free base

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist.

For research use only. Not for human or veterinary use.

Target Dopamine Receptor

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Bromopride structure

CAS No.: 4093-35-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 550.00	BP-02384-500mg	In stock	Get quote
1 g	USD 800.00	BP-02384-1g	Inquire	Get quote
2 g	USD 1,200.00	BP-02384-2g	In stock	Get quote
5 g	USD 2,200.00	BP-02384-5g	In stock	Get quote
10 g	Inquire	BP-02384-10g	In stock	Inquire

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Description

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting).

Biological activity

In Vitro Axon regeneration assay: Bromopride (100 μM; 5 d) significantly promotes axon regeneration in a rat cortical neuron scratch injury model and reversed the inhibitory effect of chondroitin sulfate proteoglycan (CSPG) on axon growth[1]. Metabolite analysis assay: Bromopride (10 μM; 4 h) can be metabolized into 20 metabolites in mouse, rat, rabbit, dog, monkey and human hepatocytes. In Vivo Rat sexual behavior model: Bromopride (20-60 mg; intravenous injection; single dose) dose-dependently inhibited male rat mating behavior (such as prolonged post-ejaculation latency) and increased serum prolactin levels[2]. Rat peritonitis model: Bromopride (1 mg/kg; subcutaneous injection; every 12 hours; 3/7 days) significantly reduced abdominal wall wound edema and fibrin deposition in Wistar rats with induced peritonitis 7 days after surgery, without affecting wound breaking strength

Identifiers

SMILES: O=C(NCCN(CC)CC)C1=CC(Br)=C(N)C=C1OC
InChIKey: GIYAQDDTCWHPPL-UHFFFAOYSA-N

Specifications

MW (average): 344.2470
Formula: C₁₄H₂₂BrN₃O₂
CAS No.: 4093-35-0
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 170 mg/mL

Documents

References

[1]. Huebner EA, et al. Diltiazem Promotes Regenerative Axon Growth. Mol Neurobiol. 2019 Jun;56(6):3948-3957.

[2]. Dunne CE, et al. Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metab Pharmacokinet. 2013;28(6):453-61.

[3]. Oliveira MV, et al. Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats. Acta Cir Bras. 2011 Dec;26(6):433-7.

Same target

Search Dopamine Receptor

Same research area

Search Neurological Disease