JNK 9L free base

JNK-9L is a BBB-penetrable and ATP-competitive JNK inhibitor.

For research use only. Not for human or veterinary use.

Target JNK Reactive Oxygen Species (ROS)

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

JNK 9L structure

CAS No.: 1128096-64-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 435.00	BP-00005-100mg	In stock	Get quote
250 mg	USD 695.00	BP-00005-250mg	In stock	Get quote
500 mg	USD 1,055.00	BP-00005-500mg	In stock	Get quote
1 g	Inquire	BP-00005-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148 ?μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin-induced ROS generation with an IC50 of 0.8 ?nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research.

Identifiers

SMILES: FC1=CC(=CC(=C1)N2CCOCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5N=C(N=C5)N6CCOCC6
InChIKey: AHMHIFXJPSHHPH-UHFFFAOYSA-N

Specifications

MW (average): 502.5434
Formula: C₂₆H₂₇FN₈O₂
CAS No.: 1128096-64-9
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 50 mg/mL

Documents

References

[1]. Kamenecka T, et al. Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors. J Med Chem. 2010 Jan 14;53(1):419-31.

Same target

Search JNK

Same research area

Search Neurological Disease