MDM2-IN-1 free base

MDM2 ligand 5 is a Ligand for E3 Ligase that can be used for the synthesis of PROTACs .

For research use only. Not for human or veterinary use.

Target Ligands for E3 Ligase MDM-2/p53

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MDM2-IN-1 structure

CAS No.: 1410737-09-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 798.00	BP-01267-50mg	In stock	Get quote
100 mg	USD 1,398.00	BP-01267-100mg	In stock	Get quote
250 mg	USD 2,598.00	BP-01267-250mg	In stock	Get quote
500 mg	Inquire	BP-01267-500mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

MDM2 ligand 5 is a Ligand for E3 Ligase that can be used for the synthesis of PROTACs .

Biological activity

Duocarmycin TM is an exceptionally potent antitumor antibiotic. Duocarmycin TM is a DNA alkylator.

Identifiers

SMILES: O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)O
InChIKey: GQQZEPFAYBPYQU-GEQKSPFYSA-N

Specifications

MW (average): 463.3290
Formula: C₂₃H₂₁Cl₂FN₂O₃
CAS No.: 1410737-09-5
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light; In solvent -20°C, 1 month;

Solubility

Soluble in DMSO/DMF

In vitro: DMSO : 22 mg/mL DMF : 10 mg/mL

Documents

References

[1]. Acharyya RK, et al. MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration. J Med Chem. 2025 Jul 10;68(13):13249-13267.

Same target

Search Ligands for E3 Ligase

Same research area

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