VH-032 free base · Synonyms: VH-032

VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

For research use only. Not for human or veterinary use.

Target Ligands for E3 Ligase

Research area Cancer

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Data Sheet SDS COA

VH-032 structure

CAS No.: 1448188-62-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 735.00	BP-02362-1g	In stock	Get quote
2 g	USD 1,285.00	BP-02362-2g	In stock	Get quote
3 g	USD 1,860.00	BP-02362-3g	In stock	Get quote
5 g	USD 2,350.00	BP-02362-5g	In stock	Get quote
10 g	Inquire	BP-02362-10g	In stock	Inquire

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Description

VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs.

Biological activity

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

Identifiers

SMILES: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C)=O)=O)=O)C=C2
InChIKey: GFVIEZBZIUKYOG-SVFBPWRDSA-N

Specifications

MW (average): 472.6000
Formula: C₂₄H₃₂N₄O₄S
CAS No.: 1448188-62-2
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 year.

Solubility

Soluble in DMSO

In vitro: DMSO：100 mg/mL

Documents

References

[1]. Michael Zengerle, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

[2]. Carles Galdeano, et al. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem. 2014 Oct 23;57(20):8657-63.

[3]. Kwok-Ho Chan, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

Same target

Search Ligands for E3 Ligase

Same research area

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