PT-179 free base · Synonyms: PT 179 · PT179

PT-179 is a selective molecular glue and thalidomide derivative, binds CRBN with a Kd of 587 nM, does not induce degradation of known pomalidomide…

For research use only. Not for human or veterinary use.

Target Ligands for E3 Ligase Molecular Glues

Research area Cancer

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Data Sheet SDS COA

PT-179 structure

CAS No.: 2924858-25-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 320.00	BP-00063-1g	In stock	Get quote
5 g	USD 960.00	BP-00063-5g	In stock	Get quote
10 g	Inquire	BP-00063-10g	In stock	Inquire

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Description

PT-179 is a selective molecular glue and thalidomide derivative, binds CRBN with a Kd of 587 nM, does not induce degradation of known pomalidomide neosubstrates.

Biological activity

In Vitro SD40 is a degradation tag specific for PT-179. PT-179 (1-10 μM; 24 h) can induce eGFP degradation in HEK293T cells. The higher the evolution degree of the degron variant, the stronger the degradation efficiency of the corresponding tagged protein.

Specifications

MW (average): 343.3340
Formula: C₁₇H₁₇N₃O₅
CAS No.: 2924858-25-1
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Mercer JAM, DeCarlo SJ, Roy Burman SS, et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science. 2024;383(6688):eadk4422. doi:10.1126/science.adk4422

Same target

Search Ligands for E3 Ligase

Same research area

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