(±)-H3RESCA-TFP free base · Synonyms: (±)-H3L28 | Rac-H3RESCA-TFP

(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA).

For research use only. Not for human or veterinary use.

Target Drug Derivative

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(±)-H3RESCA-TFP structure

CAS No.: 1919794-40-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 550.00	BP-02176-50mg	In stock	Get quote
100 mg	USD 860.00	BP-02176-100mg	In stock	Get quote
250 mg	USD 1,750.00	BP-02176-250mg	In stock	Get quote
500 mg	USD 2,800.00	BP-02176-500mg	In stock	Get quote

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Description

(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine) .

Biological activity

In Vitro The aluminum fluoride restrained complexing agent (Al18F-RESCA) method combines the chemical advantages of a chelator-based radiolabeling method with the unique physical properties of the radionuclide of choice, fluorine-18. Proteins of interest can be conjugated to RESCA via amine coupling using (±)-H3RESCA-TFP. Al18F-labeled proteins can be obtained with moderate (12-17 GBq/μmol) to good (80-85 GBq/μmol) apparent molar activity, depending on the starting activity of 18F-.

Identifiers

SMILES: O=C(CC1=CC=C(CN(CC(O)=O)[C@@H]2CCCC[C@H]2N(CC(O)=O)CC(O)=O)C=C1)OC3=C(F)C(F)=CC(F)=C3F
InChIKey: GKFBSFKLJKSHSZ-WOJBJXKFSA-N

Specifications

MW (average): 584.5134
Formula: C₂₇H₂₈F₄N₂O₈
CAS No.: 1919794-40-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃, 3 years; In solvent -20℃, 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Cleeren F, et al. Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al18F-RESCA method. Nat Protoc. 2018 Oct;13(10):2330-2347.

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