CARM1-IN-1 free base

CARM1-IN-1 is a potent and specific CARM1 inhibitor.

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CARM1-IN-1 structure

CAS No.: 1020399-49-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 450.00	BP-01827-100mg	In stock	Get quote
250 mg	USD 720.00	BP-01827-250mg	In stock	Get quote
500 mg	USD 1,080.00	BP-01827-500mg	In stock	Get quote
1 g	Inquire	BP-01827-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).

Biological activity

In Vitro CARM1-IN-1 (compound 7g) (100 μM; 90 min) inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3), such as Flag-PABP1 methylation, without inhibitory activity against HKMTs. CARM1-IN-1 (compound 7g) (8 μM; 42-44 h) inhibits PSA promoter activity in luciferase assay in LNCaP cells, without affecting cell viability.

Identifiers

SMILES: O=C1/C(CN(C/C1=C\C2=CC=C(C(Br)=C2)O)CC3=CC=CC=C3)=C/C4=CC=C(C(Br)=C4)O
InChIKey: KNMFTTWVELIVCC-CLVAPQHMSA-N

Specifications

MW (average): 555.2580
Formula: C₂₆H₂₁Br₂NO₃
CAS No.: 1020399-49-8
Physical state: Solid
Color: Yellow to Orange
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

Same target

Search Histone Methyltransferase

Same research area

Search Cancer