(-)-JQ1 free base

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1.

For research use only. Not for human or veterinary use.

Target Epigenetic Reader Domain

Research area Cancer

Purity >98% Stock Inquire

(-)-JQ1 structure

CAS No.: 1268524-71-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 380.00	BP-02473-500mg	In stock	Get quote
1 g	USD 600.00	BP-02473-1g	In stock	Get quote
2 g	USD 972.00	BP-02473-2g	In stock	Get quote
3 g	USD 1,160.00	BP-02473-3g	In stock	Get quote
5 g	USD 1,550.00	BP-02473-5g	In stock	Get quote
10 g	USD 2,490.00	BP-02473-10g	In stock	Get quote

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Description

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

Biological activity

In Vitro (R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).

Identifiers

SMILES: CC1=NN=C2[C@@H](CC(=O)OC(C)(C)C)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1
InChIKey: DNVXATUJJDPFDM-QGZVFWFLSA-N

Specifications

MW (average): 456.9880
Formula: C₂₃H₂₅ClN₄O₂S
CAS No.: 1268524-71-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year;

Solubility

Soluble in DMSO

Documents

CoA On request
Handling Instructions

References

[1].Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.

[2].Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

Same target

Search Epigenetic Reader Domain

Same research area

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