BI-847325 free base · Synonyms: BI 847325 · BI847325

BI-847325 is an ATP competitive dual inhibitor of MEK.

For research use only. Not for human or veterinary use.

Target MEK Aurora Kinase Apoptosis

Research area Cancer

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Data Sheet SDS COA

BI-847325 structure

CAS No.: 1207293-36-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 400.00	BP-01853-250mg	In stock	Get quote
500 mg	USD 650.00	BP-01853-500mg	In stock	Get quote
1 g	USD 1,050.00	BP-01853-1g	In stock	Get quote
5 g	Inquire	BP-01853-5g	Inquire	Inquire

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Description

BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. BI-847325 is a click chemistry reagent.

Biological activity

BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. BI-847325 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Identifiers

SMILES: CCNC(=O)C#CC1=CC2=C(C=C1)\C(C(=O)N2)=C(\NC1=CC=C(CN(C)C)C=C1)C1=CC=CC=C1
InChIKey: FLBNLJLONKAPLR-DQSJHHFOSA-N

Specifications

MW (average): 464.5582
Formula: C₂₉H₂₈N₄O₂
CAS No.: 1207293-36-4
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Sini P, et al. Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol Cancer Ther. 2016 Oct;15(10):2388-2398.

Same target

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Same research area

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