AZD-0284 free base · Synonyms: Related CAS 2101291-12-5

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ.

For research use only. Not for human or veterinary use.

Target ROR

Research area Inflammation/Immunology

Purity >99% Stock Inquire

Data Sheet SDS COA

AZD-0284 structure

CAS No.: 2101291-07-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 350.00	BP-01971-100mg	In stock	Get quote
250 mg	USD 550.00	BP-01971-250mg	In stock	Get quote
500 mg	USD 850.00	BP-01971-500mg	In stock	Get quote
1 g	USD 1,250.00	BP-01971-1g	In stock	Get quote
5 g	Inquire	BP-01971-5g	Inquire	Inquire

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Description

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.

Biological activity

In Vitro AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells. AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.

Identifiers

SMILES: CC(N1CC2=C(C=CC(S(=O)(C)=O)=C2)[C@@H]1C(NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3)=O)=O
InChIKey: QYYZXEPEVBXNNA-QGZVFWFLSA-N

Specifications

MW (average): 524.4330
Formula: C₂₁H₁₈F₆N₂O₅S
CAS No.: 2101291-07-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, stored under nitrogen; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 Drug Design and Delivery Symposium 26 October 2017

[2]. Asimus S, et al. Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284 [published online ahead of print, 2020 Feb 17]. Br J Clin Pharmacol. 2020;10.1111/bcp.14253.

Same target

Search ROR

Same research area

Search Inflammation/Immunology