AZD-0284 free base · Synonyms: Related CAS 2101291-12-5
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ.
For research use only. Not for human or veterinary use.
AZD-0284 structure
CAS No.: 2101291-07-8
Pack sizes & pricing
Description
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.
Biological activity
In Vitro AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells. AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.
Identifiers
- SMILES
-
CC(N1CC2=C(C=CC(S(=O)(C)=O)=C2)[C@@H]1C(NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3)=O)=O - InChIKey
-
QYYZXEPEVBXNNA-QGZVFWFLSA-N
Specifications
- MW (average)
- 524.4330
- Formula
- C21H18F6N2O5S
- CAS No.
- 2101291-07-8
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4°C, stored under nitrogen; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 100 mg/mL