NAS-181 free base · Synonyms: NAS 181 · NAS181
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B antagonist.
For research use only. Not for human or veterinary use.
NAS-181 structure
CAS No.: 205242-62-2
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 585.00 | BP-01964-25mg | In stock | Get quote |
| 50 mg | USD 936.00 | BP-01964-50mg | In stock | Get quote |
| 100 mg | USD 1,388.00 | BP-01964-100mg | In stock | Get quote |
| 250 mg | USD 2,040.00 | BP-01964-250mg | In stock | Get quote |
| 500 mg | USD 2,890.00 | BP-01964-500mg | In stock | Get quote |
| 1 g | Inquire | BP-01964-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
Biological activity
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.) NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions
Identifiers
- SMILES
-
CS(=O)(O)=O.[C@@H]1(CNCCO1)COC2=C3C(C=C(CO3)CN4CCOCC4)=CC=C2 - InChIKey
-
JDFGAOJLDPTWBF-UNTBIKODSA-N
Specifications
- MW (average)
- 442.5260
- Formula
- C20H30N2O7S
- CAS No.
- 205242-62-2
- Physical state
- Solid
- Color
- off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO