MAK683 free base · Synonyms: MAK-683 · MAK 683

MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2; has IC50s of 59, 89, 26 nM…

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MAK683 structure

CAS No.: 1951408-58-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 680.00	BP-01953-500mg	In stock	Get quote
1 g	USD 980.00	BP-01953-1g	In stock	Get quote
2 g	Inquire	BP-01953-2g	In stock	Inquire
5 g	Inquire	BP-01953-5g	Inquire	Inquire

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Description

MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2; has IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay.

Biological activity

In Vitro MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 after 14 days of treatment with an IC50 of 30 nM[1].

Identifiers

SMILES: CC1=C(C=CC=N1)C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12
InChIKey: XLIBABIFOBYHSV-UHFFFAOYSA-N

Specifications

MW (average): 376.3870
Formula: C₂₀H₁₇FN₆O
CAS No.: 1951408-58-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO >50mg/mL; Insoluble in water

Documents

References

[1]. Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.

[2]. Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.

Same target

Search Histone Methyltransferase

Same research area

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