Bisegliptin other · Synonyms: KRP-104

Bisegliptin (KRP-104) is a small molecule compound with antidiabetic activity.

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Bisegliptin structure

CAS No.: 862501-61-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 475.00	BP-01855A-10mg	In stock	Get quote
25 mg	USD 880.00	BP-01855A-25mg	In stock	Get quote
50 mg	USD 1,400.00	BP-01855A-50mg	In stock	Get quote
100 mg	USD 2,250.00	BP-01855A-100mg	In stock	Get quote
250 mg	USD 4,500.00	BP-01855A-250mg	In stock	Get quote
500 mg	Inquire	BP-01855A-500mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Bisegliptin (KRP-104) is a small molecule compound with antidiabetic activity. Bisegliptin is metabolized mainly by converting the cyano group to the carboxylic acid form, and DPP-4 plays a partial role in its metabolism. The carboxylic acid metabolite of bisegliptin can be detected both in vivo and in vitro. In rat experiments, the plasma concentration of the carboxylic acid metabolite of bisegliptin was affected by other DPP inhibitors, showing the complexity of its metabolic process. The amide intermediate of bisegliptin was detected both in vivo and in vitro, and its conversion rate was significantly faster than that of the parent compound when incubated with DPP-4 .

Identifiers

SMILES: C(OCC)(=O)C12CCC(NCC(=O)N3[C@H](C#N)C[C@H](F)C3)(CC1)CC2
InChIKey: AKFNKZFJBFQFAA-DIOPXHOYSA-N

Specifications

MW (average): 351.4157
Formula: C₁₈H₂₆FN₃O₃
CAS No.: 862501-61-9
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Kong F, Pang X, Zhao J, et al. Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases. Drug Metab Dispos. 2019;47(3):238-248. doi:10.1124/dmd.118.084640

Same target

Search Histone Methyltransferase

Same research area

Search Metabolic Disease