EED226-COOH free base

EED226-COOH is an EED226-derived ligand.

For research use only. Not for human or veterinary use.

Target Ligands for Target Protein for PROTAC Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

EED226-COOH structure

CAS No.: 2467965-71-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 450.00	BP-02022-250mg	In stock	Get quote
500 mg	USD 650.00	BP-02022-500mg	In stock	Get quote
1 g	USD 880.00	BP-02022-1g	In stock	Get quote
2 g	Inquire	BP-02022-2g	In stock	Inquire
5 g	Inquire	BP-02022-5g	Inquire	Inquire

Need another size or custom synthesis? Request a quote.

Description

EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2.

Biological activity

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Identifiers

SMILES: O=C(C1=CC=C(C2=CN=C(N3C=NN=C23)NCC4=CC=CO4)C=C1)O
InChIKey: MTAJESLOWNUVMU-UHFFFAOYSA-N

Specifications

MW (average): 335.3168
Formula: C₁₇H₁₃N₅O₃
CAS No.: 2467965-71-3
Physical state: Solid
Color: off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 125 mg/mL

Documents

References

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.

Same target

Search Ligands for Target Protein for PROTAC

Same research area

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