Duocarmycin TM free base · Synonyms: CBI-TMI

Duocarmycin TM is a potent antitumor antibiotic.

For research use only. Not for human or veterinary use.

Target ADC Payloads DNA Alkylator/Crosslinker Antibiotic

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Duocarmycin TM structure

CAS No.: 157922-77-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 688.00	BP-01247-50mg	In stock	Get quote
100 mg	USD 988.00	BP-01247-100mg	In stock	Get quote
250 mg	USD 1,698.00	BP-01247-250mg	In stock	Get quote
500 mg	Inquire	BP-01247-500mg	In stock	Inquire
1 g	Inquire	BP-01247-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.

Biological activity

In Vitro Duocarmycin TM (60 μM; 4 d; BJAB and WSU-DLCL2 cells) is a cytotoxic agent that inhibits the proliferation of tumor cells

Identifiers

SMILES: ClC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1
InChIKey: NRHDGIYFJJUFKN-CQSZACIVSA-N

Specifications

MW (average): 466.9140
Formula: C₂₅H₂₃ClN₂O₅
CAS No.: 157922-77-5
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

In vitro: DMSO : ≥ 50 mg/mL

Documents

References

[1]. Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274.

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