FR900098 sodium free base

FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase.

For research use only. Not for human or veterinary use.

Target Antibiotic Parasite

Research area Infection

Purity >98% Stock Inquire

Data Sheet SDS COA

FR900098 sodium structure

CAS No.: 73226-73-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 350.00	BP-02428-25mg	In stock	Get quote
50 mg	USD 570.00	BP-02428-50mg	In stock	Get quote
100 mg	USD 910.00	BP-02428-100mg	In stock	Get quote
250 mg	USD 1,820.00	BP-02428-250mg	In stock	Get quote
500 mg	USD 2,900.00	BP-02428-500mg	In stock	Get quote
1 g	USD 4,670.00	BP-02428-1g	In stock	Get quote
2 g	Inquire	BP-02428-2g	In stock	Inquire

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Description

FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .

Identifiers

SMILES: O=C(C)N(CCCP(O)(O[Na])=O)O
InChIKey: LCFXFDGYDKNWMD-UHFFFAOYSA-M

Specifications

MW (average): 219.1081
Formula: C₅H₁₁NNaO₅P
CAS No.: 73226-73-0
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 month;

Documents

References

[1].Okuhara M, et al. Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. J Antibiot (Tokyo). 1980 Jan;33(1):13-7.

[2].Wiesner J, et al. FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence. 2016 Aug 17;7(6):718-28.

[3].Verbrugghen T, et al. Synthesis and evaluation of α-halogenated analogues of 3-(acetylhydroxyamino) propylphosphonic acid (FR900098) as antimalarials[J]. Journal of medicinal chemistry, 2010, 53(14): 5342-5346.

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