Pafuramidine maleate free base

Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine.

For research use only. Not for human or veterinary use.

Target Parasite Antibiotic

Research area Infection

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Data Sheet SDS COA

Pafuramidine maleate structure

CAS No.: 837369-26-3

Download structure (.mol)

Pack sizes & pricing

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Description

Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine. Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.

Identifiers

SMILES: C(=C\C(O)=O)\C(O)=O.C(NOC)(=N)C1=CC=C(C=2OC(=CC2)C3=CC=C(C(NOC)=N)C=C3)C=C1
InChIKey: SWMNGXODFOCPKQ-BTJKTKAUSA-N

Specifications

MW (average): 480.4700
Formula: C₂₄H₂₄N₄O₇
CAS No.: 837369-26-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Solubility

In vitro: DMSO

Documents

References

[1]. Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53(3):953-7.

[2]. Pohlig G, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS Negl Trop Dis. 2016 Feb 16;10(2):e0004363.

[3]. Chen D, et al. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. Expert Rev Anti Infect Ther. 2007 Dec;5(6):921-8.

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