Fosmidomycin sodium free base

Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive…

For research use only. Not for human or veterinary use.

Target Bacterial Antibiotic

Research area Infection

Purity >98% Stock Inquire

Data Sheet SDS COA

Fosmidomycin sodium structure

CAS No.: 66508-37-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 315.00	BP-02429-10mg	In stock	Get quote
25 mg	USD 630.00	BP-02429-25mg	In stock	Get quote
50 mg	USD 1,000.00	BP-02429-50mg	In stock	Get quote
100 mg	USD 1,610.00	BP-02429-100mg	In stock	Get quote
250 mg	USD 3,220.00	BP-02429-250mg	In stock	Get quote
500 mg	USD 5,160.00	BP-02429-500mg	In stock	Get quote
1 g	Inquire	BP-02429-1g	In stock	Inquire

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Description

Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

Biological activity

In Vitro Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria. In Vivo Animals treated intraperitoneally with dosages of >10 mg/kg of fosmidomycin are apparently free of parasites. After treatment with 5 mg/kg of fosmidomycin, parasitemias are <1%. Animals treated orally with 50 or 100 mg/kg of fosmidomycin are apparently free of parasites, and parasitemias are <1% after treatment with 20 mg/kg of drug. Recrudescence is observed when the treatment is terminated after 4 days. Mice treated with 30 mg/kg of fosmidomycin over a period of 8 days are totally cured.

Identifiers

SMILES: OP(CCCN(C=O)O)(O[Na])=O
InChIKey: ZZPUYRHMTGOTEU-UHFFFAOYSA-M

Specifications

MW (average): 205.0815
Formula: C₄H₉NNaO₅P
CAS No.: 66508-37-0
Physical state: Solid
Color: White to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: -20°C, sealed storage, away from moisture

Solubility

Soluble in H2O : 25 mg/mL

Documents

References

[1].Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8.

[2].Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90.

[3].Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6.

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