Melflufen hydrochloride salt form · hydrochloride · Parent Melflufen

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent.

For research use only. Not for human or veterinary use.

Target DNA Alkylator/Crosslinker Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Melflufen hydrochloride structure

CAS No.: 380449-54-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 680.00	BP-02431A-100mg	In stock	Get quote
250 mg	USD 1,360.00	BP-02431A-250mg	In stock	Get quote
500 mg	USD 2,170.00	BP-02431A-500mg	In stock	Get quote
1 g	USD 3,480.00	BP-02431A-1g	In stock	Get quote
2 g	USD 5,570.00	BP-02431A-2g	In stock	Get quote
3 g	Inquire	BP-02431A-3g	In stock	Inquire

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BP-02431 — Melflufen

Description

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .

Biological activity

In Vitro Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner. ? Melflufen hydrochloride induces apoptosis in MM.1S cells. ? Melflufen hydrochloride also is a potent activator of exosome secretion. In Vivo Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.

Identifiers

SMILES: O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O.[H]Cl
InChIKey: ZCMWSKHHXLCVHI-VROPFNGYSA-N

Specifications

MW (average): 534.8790
Formula: C₂₄H₃₁Cl₃FN₃O₃
CAS No.: 380449-54-7
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO/H2O

Documents

References

[1].Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031.

[2].Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409.

[3].McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.

Same target

Search DNA Alkylator/Crosslinker

Same research area

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