S-Me-DM4 free base

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme.

For research use only. Not for human or veterinary use.

Target ADC Payloads

Research area Others

Purity >98% Stock Inquire

Data Sheet SDS COA

S-Me-DM4 structure

CAS No.: 890654-03-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 mg	USD 320.00	BP-00029-1mg	In stock	Get quote
5 mg	USD 680.00	BP-00029-5mg	In stock	Get quote
10 mg	USD 1,080.00	BP-00029-10mg	In stock	Get quote
25 mg	USD 2,100.00	BP-00029-25mg	In stock	Get quote
50 mg	USD 3,400.00	BP-00029-50mg	In stock	Get quote
100 mg	USD 5,500.00	BP-00029-100mg	In stock	Get quote

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Description

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule.

Identifiers

SMILES: C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(SC)(C)C)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
InChIKey: AYWIIXDQRUFQGH-SIDGEOBYSA-N

Specifications

MW (average): 794.3940
Formula: C₃₉H₅₆ClN₃O₁₀S
CAS No.: 890654-03-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, protect from light, stored under nitrogen; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.

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