I-BET151 free base · Synonyms: GSK1210151A | I-BET 151

I-BET151 is a BET bromodomain inhibitor.

For research use only. Not for human or veterinary use.

Target Epigenetic Reader Domain

Research area Cancer

Purity >98% Stock Inquire

I-BET151 structure

CAS No.: 1300031-49-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 450.00	BP-02330-100mg	In stock	Get quote
250 mg	USD 700.00	BP-02330-250mg	In stock	Get quote
500 mg	USD 1,050.00	BP-02330-500mg	In stock	Get quote
1 g	USD 1,550.00	BP-02330-1g	In stock	Get quote
5 g	Inquire	BP-02330-5g	In stock	Inquire
10 g	Inquire	BP-02330-10g	In stock	Inquire

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Description

I-BET151 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.

Biological activity

I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.

Identifiers

SMILES: COC1=C(C=C2N=CC3=C(N([C@H](C)C4=CC=CC=N4)C(=O)N3)C2=C1)C1=C(C)ON=C1C
InChIKey: VUVUVNZRUGEAHB-CYBMUJFWSA-N

Specifications

MW (average): 415.4445
Formula: C₂₃H₂₁N₅O₃
CAS No.: 1300031-49-5
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO >100 mg/mL

Documents

CoA On request
Handling Instructions

References

[1]. Seal J, et al. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72.

[2]. Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705.

Same target

Search Epigenetic Reader Domain

Same research area

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