PLX-3618 free base · Synonyms: PLX 3618 · PLX3618

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM.

For research use only. Not for human or veterinary use.

Target Molecular Glues Epigenetic Reader Domain Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

PLX-3618 structure

CAS No.: 2851986-76-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 420.00	BP-02203-25mg	In stock	Get quote
50 mg	USD 670.00	BP-02203-50mg	In stock	Get quote
100 mg	USD 1,070.00	BP-02203-100mg	In stock	Get quote
250 mg	USD 2,140.00	BP-02203-250mg	In stock	Get quote
500 mg	USD 3,420.00	BP-02203-500mg	In stock	Get quote

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Description

PLX-3618 is a selective BRD4 molecular glue degrader with a DC50 of 12.2 nM. PLX-3618 promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ligase substrate receptor DCAF11. PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in acute myeloid leukemia (AML) cells. PLX-3618 can be used in studies related to acute myeloid leukemia (AML)[1].

Identifiers

SMILES: O=C(N)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(C5=CC=CC(NC(C6=C7N(C=CC=N7)N=C6)=O)=C5)C=C4)=N1
InChIKey: KGEBVZGNEUJHIO-VWLOTQADSA-N

Specifications

MW (average): 601.6810
Formula: C₃₂H₂₇N₉O₂S
CAS No.: 2851986-76-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Parker GS, et al. Discovery of Monovalent Direct Degraders of BRD4 that Act via the Recruitment of DCAF11. Mol Cancer Ther. 2024;23(10):1446-1458.

Same target

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Same research area

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