UNC8153 TFA salt form · salt · Parent UNC8153 TFA · Synonyms: UNC8153 trifluoroacetate salt | UNC8153 (trifluoroacetate salt)

UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM.

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

UNC8153 TFA structure

CAS No.: 2929304-61-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 498.00	BP-02259A-50mg	In stock	Get quote
100 mg	USD 766.00	BP-02259A-100mg	In stock	Get quote
250 mg	USD 989.00	BP-02259A-250mg	In stock	Get quote
500 mg	USD 1,768.00	BP-02259A-500mg	Inquire	Get quote
1 g	USD 2,685.00	BP-02259A-1g	In stock	Get quote
5 g	Inquire	BP-02259A-5g	In stock	Inquire

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Description

UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2.

Biological activity

UNC8153 TFA (0-20 μM, 96 h) exhibits anti-adhesion effect in KMS11 cell, and exhibits mild cytotoxicity against MM1S cell

Identifiers

SMILES: O=C(C(F)(F)F)O.O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C(C(NCCCCCCN)=O)C=C5
InChIKey: PRNFABQCXAELBV-UHFFFAOYSA-N

Specifications

MW (average): 697.7007
Formula: C₃₅H₃₈F₃N₅O₇
CAS No.: 2929304-61-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: -20°C, sealed storage, away from moisture

Solubility

Soluble in DMSO, H2O

In vitro: DMSO : 100 mg/mL H2O : 12.5 mg/mL

Documents

References

[1]. Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188.

Same target

Search Histone Methyltransferase

Same research area

Search Cancer